One of America's top research scientists and his bumbling narrator cruise the endless urban maze of Los Angeles to determine if, as screenwriter William Goldman once stated, "Nobody knows anything about what makes a movie work." They discover that the movie business is not just a crap shoot - the enigmatic science of bio-psychology guides secretly guides all blockbuster hits. But as their study of Hollywood's creative development process slowly degenerates into a raunchy road trip, their entertaining documentary about movies becomes a hilarious movie about documentaries.